Closer to a Cancer Cure? Website: https://pubmed.ncbi.nlm.nih.gov/. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Studies have shown improvements in liver function in people with liver diseases who have taken a milk thistle supplement, suggesting it could help reduce liver inflammation and liver damage (9). However, human studies are limited and havent yet shown any beneficial effects. Effects of Silybum marianum (L.) Gaertn. It is possibly effective in diabetes and indigestion (). Also known as Silybum marianum, milk thistle is a perennial herb native to many continents and countries across the globe, including Southern Europe, Southern Russia, Asia Minor, Northern Africa, and the Americas. 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Trigonella foenum-graecum(fenugreek)also is used for this reason. Milk thistle is generally considered safe when taken by mouth (1, 45). doi:10.1002/14651858.CD003620.pub3, Gillessen A, Schmidt HH. sharing sensitive information, make sure youre on a federal All rights reserved. 2022 Nov 29;23(23):14968. doi: 10.3390/ijms232314968. Osteoporosis is a disease caused by progressive bone loss. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. Do not take milk thistle without medical advice if you are using a medication to treat any of the following conditions: any type of infection (including HIV, malaria, or tuberculosis); arthritis pain, occasional pain, or tension headaches (including Advil, Motrin, or Celebrex); heartburn or gastroesophageal reflux disease (GERD); high blood pressure, high cholesterol, or a heart condition; psoriasis, rheumatoid arthritis, or other autoimmune disorders; This list is not complete. However, there are currently no human studies examining the effects of milk thistle in people with Alzheimers or other neurological conditions like dementia and Parkinsons. Milk thistle may not be safe for everyone. 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971. 1. Not available for orders containing UltraNourish. https://www.micromedexsolutions.com. Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. The irony of this list of side effects being associated with drugs intended to treat anxiety, depression, and OCD is not lost on us, and ultimately begs the question, What naturally helps OCD?. One reported effect of milk thistle is that it can boost breast milk production in lactating mothers. Pharmacol Rev. By lowering LDL "bad" cholesterol levels, milk thistle may lower the chance of developing heart disease. Quality and active ingredients in supplements may vary widely from maker to maker. Milk thistle is not recommended for children. Accessed Oct. 30, 2020. Its anti-inflammatory and antioxidant properties mean that it is possibly neuroprotective and could help prevent the decline in brain function you experience as you age (14, 15). Risks. HHS Vulnerability Disclosure, Help The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Milk Thistle Can Help Fight Symptoms of OCD - Natural Wellness Update Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. If you take any medicines regularly, talk to your doctor before you start using milk thistle. Milk thistle is a plant named for the white veins on its large prickly leaves. Milk thistle is promoted as a dietary supplement for . Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Some people have nausea, diarrhea, itching, and bloating. However, many of these potential benefits are not backed by science. 5th ed. Epub 2016 Dec 22. Questions? Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. MILK THISTLE - Uses, Side Effects, and More - WebMD How Does Cirrhosis Affect Life Expectancy? National Cancer Institute PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. While the cost of most OCD medications currently available on the market is actually quite reasonable, the common side effects that occur are definitely not. Historically, people have used milk thistle for liver disorders and gallbladder problems. metabolic syndrome, depression, cardiovascular diseases and thalassemia, in addition to its photoprotective activity in in vitro tests and preclinical studies. This site needs JavaScript to work properly. While not dangerous, it can cause scars. *These statements have not been evaluated by the Food and Drug Administration. Rev Diabet Stud. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). Accessed Oct. 30, 2020. Longe, J., ed. Its herbal remedy is known as milk thistle extract. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. These side effects may be mild or severe. Neurological Disorders Milk thistle has long been used to alleviate the inflammation commonly associated with a host of neurological disorders such as dementia, Alzheimers, and Parkinsons Disease (8). a history of endometriosis or uterine fibroids. Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. Milk thistle may also be used for purposes not listed in this product guide. BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. Thank you, {{form.email}}, for signing up. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Moreover, its unclear whether milk thistle is well enough absorbed in people to allow adequate amounts to pass through the blood-brain barrier. Cathy Wong is a nutritionist and wellness expert. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Satisfaction. 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). In: Drugs and Lactation Database (LactMed). What Are the Risks of Taking Milk Thistle? Other SSRIs on the market include Fluvoxamine (Luvox), Paroxatine (Paxil), and Sertraline (Zoloft) (3). Milk Thistle (and liver cleansing) has two workings: it supports the liver and it lowers the inactive rT3 in favour of the active T3. These products are not intended to diagnose, treat, cure, or prevent any disease. Do not use this product without medical advice if you are pregnant. the unsubscribe link in the e-mail. Anyone have experience with Milk Thistle for OCD/Anxiety? World J Gastroenterol. The therapeutic potential of milk thistle in diabetes. Malaria. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. Accessed Oct. 30, 2020. As a result, researchers suggest that milk thistle may be a useful therapy for preventing or delaying bone loss in postmenopausal women (24, 25). Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. 2012;308(3):274-282. doi:10.1001/jama.2012.8265, Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. information submitted for this request. doi:10.1515/jbcpp-2019-0206, Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . However, its currently unclear if it has the same beneficial effects in humans. The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Phytomedicine. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. People sometimes eat the stem and leaves of milk thistle in salads. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Accessed Oct. 30, 2020. Dosage and side effects. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. The benefits of milk thistle are believed to come from silymarin, an anti-inflammatory compound present throughout the entire plant, but highly concentrated in milk thistle seeds (4). Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. Memorial Sloan-Kettering Cancer Center: About Herbs: Milk thistle., Natural Standard Patient Monograph: Milk thistle.. A 2010 review by researchers found that black . . Some people also call it Mary thistle and holy thistle. Dosing of milk thistle ranged from 150 mg twice a day to 300 mg twice a day. Available for Android and iOS devices. Milk thistle often is used as a galactalogue, a food or supplement that people who are chest feeding take to improve milk production. If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. Int J Mol Sci. Large-scale, properly-designed studies are needed. It also states that Milk Thistle will lower Ferritin and that iron-supplement is advised.
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